Research Gist
In Ayurveda, Jatamansi (Nardostachys jatamansi) is classified as a hypno-sedative herb — one traditionally used to calm the mind and support rest. This study investigated how it may produce that calming effect. Mice received Jatamansi extract orally for 3, 7 or 14 days, and were compared with a group given diazepam, a reference calming compound. Four standard behavioural tests were used to assess anxiety-like behaviour. After seven days, the Jatamansi group showed calmer behaviour across all four tests, with results comparable to diazepam. Brain analysis showed increased levels of GABA — the nervous system's main calming neurotransmitter — along with increased monoamine neurotransmitters. The researchers concluded that Jatamansi's calming action is most likely mediated through the GABA receptor complex. The study also tracked how the extract distributes through the body.
Key Learnings
- Seven days of Jatamansi extract produced calmer behaviour across four standard tests.
- The calming effect was comparable to diazepam, the reference compound used.
- Brain levels of GABA, the main calming neurotransmitter, increased.
- The findings support Jatamansi's classical Ayurvedic role as a calming, rest-supporting herb.
- This was a mouse study — the same effects have not been confirmed in people.