RESEARCH LIBRARY
Where neuroscience meets ancient wisdom.
Discover research, rituals, and real-world insights for modern well-being.
AYURVEDA
The effect of nanoparticle size on the probability to cross the blood-brain barrier: an in-vitro endothelial cell model
Journal: Journal of Nanobiotechnology
Year: 2015 | Volume: 13 | Issue: No issue number | Article Number: 19
Authors: Malka Shilo, Anat Sharon, Koby Baranes, Menachem Motiei, Jean-Paul M. Lellouche, Rachela Popovtzer
PMID: 25880565 | PMCID: PMC4359781 | DOI: 10.1186/s12951-015-0075-7
AYURVEDA
Methanol extract of Smritisagara Rasa attenuates neurobehavior, neurochemical and stress indicators in rotenone-induced Drosophila model of Parkinson's disease
Publication Year: 2025
Study Type: Preclinical — In vivo (Drosophila)
Link: View on ScienceDirect
AYURVEDA
Exploring Therapeutic Potential of Smritisagar Rasa: A Review
Journal: International Journal of Applied Ayurved Research
Publication Year: 2022 | Volume: 5 | Issue: 10 | Pages: 748–755
Authors: Pund S., Dongre S.
Study Type: Review — Classical and traditional literature
Link: View on IJAAR
AYURVEDA
Pharmacological and Clinical Efficacy of Picrorhiza kurroa and Its Secondary Metabolites: A Comprehensive Review
Journal: Molecules
Publication Year: 2022 | Volume: 27 | Issue: 23 | Article Number: 8316
Authors: Almeleebia T.M., Alsayari A., Wahab S.
Study Type: Review article
PMID: 36500409 | PMCID: PMC9738980 | DOI: 10.3390/molecules27238316
AYURVEDA
Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain
Journal: Journal of Ethnopharmacology
Publication Year: 2009 | Volume: 124 | Issue: 3 | Pages: 409–415
Authors: Bihaqi S.W., Sharma M., Singh A.P., Tiwari M.
Study Type: Preclinical — In vivo (rat)
PMID: 19505562 | DOI: 10.1016/j.jep.2009.05.038
AYURVEDA
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study
Journal: Journal of Affective Disorders
Publication Year: 2017 | Volume: 207 | Pages: 188–196
Authors: Lopresti A.L., Drummond P.D.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 27723543 | Link: View on PubMed
AYURVEDA
Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
Journal: Journal of Affective Disorders
Publication Year: 2014 | Volume: 167 | Pages: 368–375
Authors: Lopresti A.L., Maes M., Maker G.L., Hood S.D., Drummond P.D.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 25046624 | Link: View on PubMed
AYURVEDA
An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood
Journal: Phytotherapy Research
Publication Year: 2014 | Volume: 28 | Issue: 4 | Pages: 551–559
Authors: Benson S., Downey L.A., Stough C., Wetherell M., Zangara A., Scholey A.
Study Type: Human — Double-Blind, Placebo-Controlled Crossover Trial
PMID: 23788517 | DOI: 10.1002/ptr.5029
AYURVEDA
Inhibition of MAO and GABA: probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice
Journal: Indian Journal of Experimental Biology
Publication Year: 2008
Authors: Dhingra D., Goyal P.K.
Study Type: Preclinical — In vivo (mouse)
PMID: 18512329 | Link: View on PubMed
AYURVEDA
Efficacy of Nardostachys jatamansi (D.Don) DC in post stroke depression: A randomized, double blind, controlled trial
Publication Year: 2023
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
Trial Registration: Clinical Trials Registry of India (CTRI)
Link: View on ScienceDirect
AYURVEDA
Anxiolytic actions of Nardostachys jatamansi via GABA benzodiazepine channel complex mechanism and its biodistribution studies
Journal: Metabolic Brain Disease
Publication Year: 2018 | Volume: 33 | Issue: 5 | Pages: 1533–1549
Authors: Razack S., Kandikattu H.K., Venuprasad M.P., Amruta N., Khanum F., Chuttani K., Mishra A.K.
Study Type: Preclinical — In vivo (mouse)
PMID: 29934858 | DOI: 10.1007/s11011-018-0261-z
AYURVEDA
Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study
Journal: Cureus
Publication Year: 2019 | Volume: 11 | Issue: 12 | Article Number: e6466
Authors: Salve J., Pate S., Debnath K., Langade D.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 32021735 | PMCID: PMC6979308 | DOI: 10.7759/cureus.6466
AYURVEDA
Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis
Journal: PLOS ONE
Publication Year: 2021 | Volume: 16 | Issue: 9 | Article Number: e0257843
Authors: Cheah K.L., Norhayati M.N., Yaacob L.H., Abdul Rahman R.
Study Type: Human — Systematic Review and Meta-Analysis of RCTs
PMID: 34559859 | PMCID: PMC8462692 | DOI: 10.1371/journal.pone.0257843
AYURVEDA
Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study
Journal: Cureus
Publication Year: 2019 | Volume: 11 | Issue: 9 | Article Number: e5797
Authors: Langade D., Kanchi S., Salve J., Debnath K., Ambegaokar D.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 31728244 | PMCID: PMC6827862 | DOI: 10.7759/cureus.5797
AYURVEDA
Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer's disease
Journal: Scientific Reports
Publication Year: 2025 | Volume: 15 | Article Number: 8103
Authors: Amrutha S., Abhinand C.S., Upadhyay S.S., Parvaje R., Prasad T.S.K., Modi P.K.
Study Type: Computational — Metabolomics and network pharmacology
PMID: 40057579 | PMCID: PMC11890609 | DOI: 10.1038/s41598-025-92756-5
AYURVEDA
Tinospora cordifolia attenuates cognitive impairment in rats with vascular dementia by suppressing TLR4/MyD88/NF-κB signaling pathway induced neuroinflammation
Journal: Alzheimer's & Dementia (Conference Abstract)
Publication Year: 2025 | Volume: 21 | Article Number: e102042
Authors: Kumar D., T A G., Krishnamurthy S., Pathak A.
Study Type: Preclinical — In vivo (rat)
PMCID: PMC12741021 | DOI: 10.1002/alz70858_102042
AYURVEDA
Tinospora cordifolia ameliorates anxiety-like behavior and improves cognitive functions in acute sleep deprived rats
Journal: Scientific Reports
Publication Year: 2016 | Volume: 6 | Article Number: 25564
Authors: Mishra R., Manchanda S., Gupta M., Kaur T., Saini V., Sharma A., Kaur G.
Study Type: Preclinical — In vivo (rat)
PMCID: PMC4857086 | DOI: 10.1038/srep25564
AYURVEDA
Evidence for involvement of the monoaminergic system in antidepressant-like activity of an ethanol extract of Boerhaavia diffusa and its isolated constituent, punarnavine, in mice
Journal: Pharmaceutical Biology
Publication Year: 2014 | Volume: 52 | Issue: 6 | Pages: 767–774
Authors: Dhingra D., Valecha R.
Study Type: Preclinical — In vivo (mouse)
PMID: 24559436 | DOI: 10.3109/13880209.2013.870583
AYURVEDA
In Vitro Antioxidant and Inhibitory Study of Picrorhiza kurroa (Kutki), Syzygium aromaticum (Loung), Lawsonia inermis (Henna), Rheum emodi (Revand Chini), Curcuma longa (Haldi) Against Lipid Per-Oxidation in Mice Brain and Liver
Journal: Dose-Response
Publication Year: 2023 | Volume: 21 | Issue: 4 | Article Number: 15593258231210431
Authors: Hassan F., Khan A.U., Zaidi S.Z.U.H., Niazi M.K., Ismail M.A.
Study Type: Preclinical — In vitro (mouse brain and liver tissue)
PMID: 37900620 | DOI: 10.1177/15593258231210431
AYURVEDA
Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis
Journal: Journal of Traditional and Complementary Medicine
Publication Year: 2018 | Volume: 8 | Issue: 4 | Pages: 483–496
Authors: Rachitha P., Krupashree K., Jayashree G.V., Kandikattu H.K., Amruta N., Gopalan N., Rao M.K., Khanum F.
Study Type: Preclinical — In vitro (neuronal cell model)
PMID: 30302329 | PMCID: PMC6174265 | DOI: 10.1016/j.jtcme.2017.11.002
AYURVEDA
In vivo investigation of the neuroprotective property of Convolvulus pluricaulis in scopolamine-induced cognitive impairments in Wistar rats
Journal: Indian Journal of Pharmacology
Publication Year: 2011 | Volume: 43 | Issue: 5 | Pages: 520–525
Authors: Bihaqi S.W., Singh A.P., Tiwari M.
Study Type: Preclinical — In vivo (rat)
PMID: 22021993 | DOI: 10.4103/0253-7613.84958
AYURVEDA
Application of Green Technologies in Design-Based Extraction of Celastrus paniculatus (Jyotishmati) Seeds, SEM, GC-MS Analysis, and Evaluation for Memory Enhancing Potential
Journal: Frontiers in Nutrition
Publication Year: 2022 | Volume: 9 | Article Number: 871183
Authors: Arya A., Kaushik D., Almeer R., Bungau S.G., Sayed A.A., Abdel-Daim M.M., Bhatia S., Mittal V.
Study Type: Preclinical — Analytical and in vivo (rodent)
PMID: 35662919 | PMCID: PMC9158750 | DOI: 10.3389/fnut.2022.871183
AYURVEDA
Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study
Journal: Nutrients
Publication Year: 2020 | Volume: 12 | Issue: 6 | Article Number: 1678
Authors: Cox K.H.M., White D.J., Pipingas A., Poorun K., Scholey A.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 32512782 | PMCID: PMC7352411 | DOI: 10.3390/nu12061678
AYURVEDA
Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
Journal: Journal of Psychopharmacology
Publication Year: 2015 | Volume: 29 | Issue: 5 | Pages: 642–651
Authors: Cox K.H.M., Pipingas A., Scholey A.B.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 25277322 | DOI: 10.1177/0269881114552744
AYURVEDA
The Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review of Randomized, Controlled Human Clinical Trials
Journal: Journal of Alternative and Complementary Medicine
Publication Year: 2012 | Volume: 18 | Issue: 7 | Pages: 647–652
Authors: Pase M.P., Kean J., Sarris J., Neale C., Scholey A.B., Stough C.
Study Type: Human — Systematic Review of Randomized Controlled Trials
PMID: 22747190 | DOI: 10.1089/acm.2011.0367
AYURVEDA
The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects
Journal: Psychopharmacology
Publication Year: 2001 | Volume: 156 | Issue: 4 | Pages: 481–484
Authors: Stough C., Lloyd J., Clarke J., Downey L.A., Hutchison C.W., Rodgers T., Nathan P.J.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 11498727 | DOI: 10.1007/s002130100815
AYURVEDA
Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial
Journal: Journal of Alternative and Complementary Medicine
Publication Year: 2008 | Volume: 14 | Issue: 6 | Pages: 707–713
Authors: Calabrese C., Gregory W.L., Leo M., Kraemer D., Bone K., Oken B.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 18611150 | DOI: 10.1089/acm.2008.0018
Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study
Journal: Evidence-Based Complementary and Alternative Medicine
Publication Year: 2021 | Article Number: 8254344
Authors: Gopukumar K. et al.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 34858513 | PMCID: PMC8632422 | DOI: 10.1155/2021/8254344
Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions
Journal: Journal of Dietary Supplements
Publication Year: 2017 | Volume: 14 | Issue: 6 | Pages: 599–612
Authors: Choudhary D., Bhattacharyya S., Bose S.
Study Type: Human — Randomized, Double-Blind, Placebo-Controlled Trial
PMID: 28471731 | DOI: 10.1080/19390211.2017.1284970
AYURVEDA
Neuroprotective efficacy of Swarna Bhasma on sleep deprived induced cognitive impairment in rats
Journal: Indian Drugs
Publication Year: 2018 | Volume: 55 | Page: 43
Authors: Khan A.Y., Sheikh A.A., Tenpe C.R., Patole A.M., Biyani K.R.
Study Type: Preclinical — In vivo (rat)
Link: View on Indian Drugs
INGREDIENTS
Curcumin attenuates α-synuclein pathology via UBC9-mediated SUMOylation in a preformed fibril Parkinson's mouse model
Publication Year: 2025
Study Type: Preclinical — In vivo (mouse, preformed fibril model)
PMCID: PMC13433455 | Link: View on PubMed Central
INGREDIENTS
Curcumin Protects Dopaminergic Neurons Against Neuroinflammation-Mediated Damage via α7-Nicotinic Acetylcholine Receptors in a 6-OHDA Rat Model
Publication Year: 2020
Authors: El Nebrisi E. et al.
Study Type: Preclinical — In vivo (rat)
PMCID: PMC7583812 | Link: View on PubMed Central
INGREDIENTS
Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model
Journal: Inflammopharmacology
Publication Year: 2018
Authors: Sharma N., Nehru B.
Study Type: Preclinical — In vivo (rat)
PMID: 29027056 | Link: View on PubMed
AYURVEDA
Neuroprotective effect of picroside II in brain injury and cerebral ischemia
Publication Year: 2016
Study Type: Preclinical — In vivo (rodent)
PMCID: PMC5209504 | Link: View on PubMed Central
AYURVEDA
Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signalling pathway in the action of neuritogenic substances on PC12D cells
Journal: European Journal of Pharmacology
Publication Year: 2000 | Volume: 406 | Issue: 2 | Pages: 203–208
Authors: Li P., Matsunaga K., Yamakuni T., Ohizumi Y.
Study Type: Preclinical — In vitro (PC12D cells)
PMID: 11041388 | Link: View on PubMed
AYURVEDA
Picrorhiza kurroa Prevents Memory Deficits by Inhibiting NLRP3 Inflammasome Activation and BACE1 Expression in 5xFAD Mice
Journal: Neurotherapeutics
Publication Year: 2020
Study Type: Preclinical — In vivo (5xFAD mouse)
PMCID: PMC7007473 | Link: View on PubMed Central
AYURVEDA
Attenuation of oxidative damage by Boerhaavia diffusa L. against different neurotoxic agents in rat brain homogenate
Publication Year: 2015
Study Type: Preclinical — In vitro (rat brain homogenate)
PMID: 26268727 | Link: View on PubMed
AYURVEDA
Neuroprotective effect of hydroalcoholic extract of Boerhaavia diffusa against MPTP-induced neurodegeneration in rats
Study Type: Preclinical — In vivo (rat)
Model: MPTP-induced neurodegeneration
Link: Search on PubMed
AYURVEDA
Enhancement of memory and synaptic plasticity by Celastrus paniculatus seed extract
Publication Year: 2025
Study Type: Preclinical — In vivo (rat)
PMCID: PMC12946647 | Link: View on PubMed Central
AYURVEDA
Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain
Journal: Journal of Ethnopharmacology
Publication Year: 2004 | Volume: 93 | Issue: 2–3 | Pages: 213–219
Authors: Godkar P. et al.
Study Type: Preclinical — In vitro (neuronal culture)
PMID: 15234755 | Link: View on PubMed
AYURVEDA
Celastrus paniculatus seed extract protects against MPP+-induced neuronal apoptosis via GSK-3β in a Parkinson's disease model
Journal: Biomedical Reports
Publication Year: 2024 | Volume: 20 | Issue: 3 | Article Number: 46
Authors: Phattanakiatsakul K. et al.
Study Type: Preclinical — In vitro
PMID: 38357231 | Link: View on PubMed
AYURVEDA
The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity
Journal: Anesthesia and Analgesia
Publication Year: 2004
Authors: Yuan C.S. et al.
Study Type: Preclinical — In vitro (rat brainstem neurons)
PMID: 14742369 | Link: View on PubMed
AYURVEDA
GABAergic effect of valeric acid from Valeriana wallichii in amelioration of ICV STZ induced dementia in rats
Journal: Revista Brasileira de Farmacognosia
Publication Year: 2016
Study Type: Preclinical — In vivo (rat)
DOI: 10.1016/j.bjp.2016.05.008
AYURVEDA
Valerian Root in Treating Sleep Problems and Associated Disorders — A Systematic Review and Meta-Analysis
Journal: Journal of Evidence-Based Integrative Medicine
Publication Year: 2020
Authors: Shinjyo N., Waddell G., Green J.
Study Type: Human — Systematic Review and Meta-Analysis
PMID: 33086877 | Link: View on PubMed
AYURVEDA
Association of L-DOPA with recovery following Ayurveda medication in Parkinson's disease
Journal: Journal of the Neurological Sciences
Publication Year: 2000
Authors: Nagashayana N. et al.
Study Type: Human — Clinical study (small sample)
PMID: 10727208 | Link: View on PubMed
AYURVEDA
Antiperoxidative and anti-inflammatory effect of Sida cordifolia methanolic extract against quinolinic acid induced neurotoxicity
Journal: Neurochemical Research
Publication Year: 2010
Authors: Swathy S.S. et al.
Study Type: Preclinical — Ex vivo / in vitro
DOI: 10.1007/s11064-010-0192-5
AYURVEDA
Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease
Journal: NeuroToxicology
Publication Year: 2013
Authors: Khurana N., Gajbhiye A.
Study Type: Preclinical — In vivo (rat)
PMID: 23994302 | Link: View on PubMed
AYURVEDA
Centella asiatica extract upregulates hippocampal BDNF/TrkB/ERK1/2 signalling pathway in chronic stress-induced rats
Publication Year: 2019
Study Type: Preclinical — In vivo (rat)
PMCID: PMC6885393 | Link: View on PubMed Central
AYURVEDA
Centella asiatica in cognitive health: neuroprotective potential and mechanisms
Journal: Evidence-Based Complementary and Alternative Medicine
Publication Year: 2012
Author: Orhan I.E.
Study Type: Review article
PMCID: PMC3359802 | Link: View on PubMed Central
AYURVEDA
Effect of Centella asiatica leaf extract on the dietary supplementation in transgenic Drosophila model of Parkinson's disease
Publication Year: 2014
Authors: Siddique Y.H. et al.
Study Type: Preclinical — In vivo (transgenic Drosophila)
PMCID: PMC4265550 | Link: View on PubMed Central